2017 Fiscal Year Final Research Report
Reprogramming of the polyketide synthase/peptide synthetase from Streptomyces
| Project/Area Number |
16K13084
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Abe Ikuro 東京大学, 大学院薬学系研究科(薬学部), 教授 (40305496)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 合成生物学 / 生合成 / 天然物化学 / 酵素工学 |
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| Outline of Final Research Achievements |
Reprogramming of the NRPS/PKS assembly line is an attractive method for the creation of novel bioactive molecules. In this study, we successfully accomplished three manipulations: i) ring contraction, ii) ring expansion, and iii) alkyl chain diversification, to generate a set of unnatural novel derivatives in practical yields. This study presented a useful strategy for engineering NRPS-PKS module enzymes.
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| Free Research Field |
生物分子科学
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