Construction of self-reproducing vesicles with self-conservation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K13983
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional solid state chemistry
• Research Institution: Suzuka National College of Technology
• Principal Investigator: Takakura Katsuto 鈴鹿工業高等専門学校, その他部局等, 准教授 (60396843)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ベシクル / 自己複製ベシクル / 両親媒性分子 / 転移反応

Outline of Final Research Achievements

The 1H NMR spectroscopic study revealed that the migration of the dodecane-1,2-diol from the amphiphilic acetal derivative (N1) to the amphiphilic acetophenone derivative (N2) occurring within amphiphilic aggregates in water proceeded to form double-chained amphiphile (V) with conversion of 60%, accompanying with the morphological transformation of amphiphilic aggregates from micelles to vesicles.Because this migration reaction was confirmed to be accelerated by p-dodecylbenzene sulfonic acid (p-DBSA), the mixture of precursors (N1, N2) was added to giant vesicles composed of V and p-DBSA (10:1). As a reult, the enlargement and division of vesicles was observed after the addition of precursors. This system can be regarded as an preliminary system for an self-reproducing vesicle.

Free Research Field

有機化学・分子集合体の化学