Development of Antibody-like Polymer Medicine by denovo designed glycopolymers

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14007
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: Kyushu University
• Principal Investigator: Miura Yoshiko 九州大学, 工学研究院, 教授 (00335069)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 糖鎖高分子 / リビングラジカル重合 / 分子認識 / デノボデザイン

Outline of Final Research Achievements

The glycopolymers were designed and prepared by the controlled radical polymerization with RAFT reagent, in order to fit the protein structure. The glycopolymers were designed based on the sugar spatial arrangement, and the kind of sugars, which bound to the specific target of sugar recognition protein (lectin, concanavalin A) and influenza viruses. Those glycopolymers were prepared via post-click chemistry and RAFT living radical polymerization. The monomers was desgined in terms of the reactivity of monomers and pi-conjugation. The controlled polymerization was carried out via RAFT reagent, and in the case of polyacrylamide, the multiblock copolymerization was attained.

Free Research Field

高分子化学