Design of peptide probes capable of recognizing highly-curved membranes for exosome analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14013
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: Tohoku University
• Principal Investigator: Sato yusuke 東北大学, 理学研究科, 助教 (90583039)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 蛍光プローブ / 両親媒性αヘリックス / エクソソーム

Outline of Final Research Achievements

We developed fluorescent probes based on amphipathic αhelix peptide (22
residues from C-terminal of ApoA-I) that can selectively recognize highly-curved membranes found in exosomes. Our method allows easier, simpler and more rapid detection of
exosomes.

Free Research Field

生命分析科学