A time-resolved analysis of intracellular signal transduction in response to non-diffusible factor

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14026
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Analytical chemistry
• Research Institution: National Institute for Materials Science
• Principal Investigator: Nakanishi Jun 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, グループリーダー (60360608)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ナノバイオ / シグナル伝達 / 細胞・組織 / 生体材料 / ケージド化合物

Outline of Final Research Achievements

Some diffusible biomolecules change their activities upon their conjugation to materials. In this project, we developed new research tools for cellular responses to material-biomolecule conjugates. We have succeeded in observation dynamic processes of estradiol or epidermal growth factor conjugated to micropatterned substrates and nanoparticles, respectively. These methods will give us useful information for the developments of new biomaterials and drugs.

Free Research Field

生体分析化学