2018 Fiscal Year Final Research Report
Preparation of uni-axially swelling gels by multi-step cross-linking of macroscopically-oriented supergiant molecules
| Project/Area Number |
16K14077
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
Kaneko Tatsuo 北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (20292047)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | ゲル / DDS / 架橋 / 多糖 / ラン藻 / 異方性 / 物質放出 |
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| Outline of Final Research Achievements |
Anisotropic gels have direction dependence in various functions such as cell adhesion and substance transport/release, and are important in the development of new functional soft matters. In conducting researches on anisotropic gels, we have found that giant rigid molecules exhibit self-orientation at a very low concentrations and form milliscaled anisotropic domains. Therefore, based on these results, a molecularly-oriented gel was created by controlling the reactivity of chemical crosslinking, and a gel that swelled in only one direction like a coil spring was developed. Moreover, we discovered that the anisotropic releasability of substances such as a pigmen.
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| Free Research Field |
高分子化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、コイルバネのように一方向のみに伸縮する究極の異方性ゲルが開発され、異方的編み目を作成するための架橋点形成に関する新規なケミストリーを展開できた。ここで得られる知見はゲル・ゴムなどの構成要素である高分子網目の新しい構造論の展開につながるため、高分子材料科学への貢献が強く期待される意義の高いものである。作成した異方的物質放出性ゲルシートを薬物送達剤システムとして活用すれば、非侵襲性医療として利用される経皮吸収システム開発において重要な知見を与える。
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