2017 Fiscal Year Final Research Report
A feasibility study for 3D neuropathology
| Project/Area Number |
16K14571
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北浦 弘樹 新潟大学, 脳研究所, 助教 (80401769)
清水 宏 新潟大学, 脳研究所, 助教 (40608767)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 神経細胞病理学 / 脳透明化技術 / てんかん |
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| Outline of Final Research Achievements |
To investigate the 3-dimensional cytoarchitecture of the cerebral cortex taken from patients with epilepsy, we developed new chemical protocols for clearing human brain tissue and driving methodology of the sheet-scanning fluorescence microscopy. By the methods, we were able to observe fine features of neurons and glia distributed widely within extremely thick brain blocks. The methods created by this feasibility study would open an innovative era for the neuropathology field.
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| Free Research Field |
神経病理学
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