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2017 Fiscal Year Final Research Report

Development new technique for mapping neuronal functions with NIR imaging

Research Project

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Project/Area Number 16K14589
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionUniversity of Tsukuba

Principal Investigator

Miwa Yoshihiro  筑波大学, 医学医療系, 講師 (70263845)

Research Collaborator KIJIMA JUNKO  筑波大学, 医学医療系, 技術職員 (30517793)
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords蛍光 / モデルマウス / 非侵襲
Outline of Final Research Achievements

Non-invasive imaging of neuronal activities in the whole brain and analysis of the correlation with behavior are expected to be a powerful approach for brain science. So we planed to make several new imaging model mice, but we found to need to solve several technical optic problems before trying to establish the initially planed model mice.
In parallel, we actually carried out Photoacoustic imaging of NIR fluorescence in living mouse brain and found that bias of signal existed depend on the type of samples. Therefore, we need to choose the suitable strategy to express NIR fluorescent proteins in brain.

Free Research Field

バイオイメージング

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Published: 2019-03-29  

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