2016 Fiscal Year Final Research Report
Structure optimization of hypoxically activated prodrug
| Project/Area Number |
16K14628
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
IKEDA Yutaka 筑波大学, 数理物質系, 研究員 (70425734)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Keywords | 低酸素 / 抗がん剤 |
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| Outline of Final Research Achievements |
In this project, we tried to reduce IC50 value of previously developed hypoxically activated anti-cancer prodrug. In previous system, drug was modified via amide bond and released by the cleavage of amide bond. In contrast, newly developed method enabled drug release by cleavage of ester bond although drug was conjugated by amide bond. IC50 value reduced by one order in the case of developed method.
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| Free Research Field |
ドラッグデリバリー
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