2018 Fiscal Year Final Research Report
Identification of target cells and the receptor for a novel hypothalamic small protein
| Project/Area Number |
16K14769
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩越 栄子 広島大学, 総合科学研究科, 研究員 (50311296)
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| Research Collaborator |
FURUMITSU megumi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 小タンパク質 / 視床下部 / 標的細胞 / 受容体 / 摂食 / 脂肪蓄積 |
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| Outline of Final Research Achievements |
We have recently identified a novel cDNA encoding a small secretory protein termed neurosecretory protein GL (NPGL) from the chicken hypothalamus. In rodents, NPGL stimulates food intake and fat accumulation. The identification of target cells and the specific receptor is essential to elucidate the physiological roles of the neuropeptide. In this study, we sought target cells and the receptor for the neuropeptide by morphological analyses. NPGL-immunoreactive fibers were observed in close anatomical contact with pro-opiomelanocortin (POMC) neurons in the rostral region of the arcuate nucleus of the hypothalamus. These results showed one of the target cells for NPGL.
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| Free Research Field |
神経内分泌学
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| Academic Significance and Societal Importance of the Research Achievements |
新たな生理活性物質の発見は、生体機能に関わる分子メカニズムの解明の糸口を与える。本研究では、我々が最近発見した新規脳因子NPGLの標的細胞と受容体の同定を進めた。その結果、これまで摂食抑制を担う神経ペプチド産生細胞（POMCニューロン）に新規脳因子NPGLの産生細胞が神経連絡をし、POMCニューロンの活動を抑制することで摂食行動を亢進している可能性を示唆する結果を得た。
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