Regulation of ovarian fuctions through exosome-mediated inter-organ communications

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15052
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: The University of Tokyo
• Principal Investigator: Sugiura Koji 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (20595623)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 卵巣卵胞

Outline of Final Research Achievements

Extra-cellular vesicles, called exosomes, contain several bioactive materials, and are now considered as novel mediators of cell-to-cell communications. This study aimed to test a possibility that exosomes produced in organs other than ovaries regulate ovarian function. The results were as follows.
1. RNA-sequencing of transcripts in porcine follicular exosomes revealed a possibility that some of follicular exosomes were originated from organs other than ovaries.
2. Follicular exosomes promoted FSH signaling in ovarian somatic cells in culture.

Free Research Field

繁殖遺伝学