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2017 Fiscal Year Final Research Report

Study for epigenetic regulation of human TERT gene

Research Project

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Project/Area Number 16K15055
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Integrative animal science
Research InstitutionUniversity of Miyazaki

Principal Investigator

Nishino Koichiro  宮崎大学, 農学部, 准教授 (90508144)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywordsエピジェネティクス / TERT遺伝子 / 細胞不死化機構
Outline of Final Research Achievements

Telomerase reverse transcriptase (TERT) is an important molecule that supports high self-proliferative capacity in stem cells. However, epigenetic regulation of tissue-specific expression for the human TERT gene is unknown. In this study, we identified the differentially DNA methylated region of the TERT gene (TERT- DMR), of which hypermethylation enhanced TERT expression. Furthermore, H3K4me3 modification was recognized in human iPS cells, onthe other hand, H3K27me3 modification and HP - 1α binding were significantly recognized in somatic cells. We showed here a new epigenetic mechanism that DNA hypermethylation acts on gene expression.

Free Research Field

幹細胞生物学

URL: 

Published: 2019-03-29  

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