Molecular mechanism underlying juvenile hormone-mediated repression of adult metamorphosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15072
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Insect science
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: Kayukawa Takumi 国立研究開発法人農業・食品産業技術総合研究機構, 生物機能利用研究部門, 主任研究員 (70580463)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 幼若ホルモン / 成虫化決定因子 / 抑制分子メカニズム / 転写因子 / 脱皮・変態

Outline of Final Research Achievements

Juvenile hormone (JH) represses precocious metamorphosis of larval to adult transitions. Ecdysone-induced protein 93F (E93) functions as an adult specifier gene in the pupal-adult transition. JH is known to repress E93 expression to prevent immature larvae from bypassing the pupal stage and progressing to precocious adult development; however, the molecular mechanism underlying JH-mediated E93 repression remains unknown. Here, I identified a cis- and tran-element concerning the repression, and demonstrated molecular mechanism underlying juvenile hormone-mediated repression of precocious larval-adult metamorphosis.

Free Research Field

昆虫生理学・生化学・分子生物学