2017 Fiscal Year Final Research Report
Approach to identify a novel mechanism which modulates vitaminA regulation of adipocyte differentiation
| Project/Area Number |
16K15090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ビタミンA / 脂肪細胞 / 細胞外マトリックス |
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| Outline of Final Research Achievements |
Differentiation of mesenchymal stem cells can be regulated by either retinoic acid, an active metabolite of vitamin A, or stiffness of extracellular matrix (ECM). We previously reported that vinexin, a focal adhesion protein, is involved in sensing ECM stiffness. Given the association of vinexin with retinoic acid receptor, it is hypothesized that retinoic acid and ECM stiffness function cooperatively for regulating the differentiation of mesenchymal stem cells. We examined the effect of vinexin depletion on retinoic acid-induced differentiation. The result partly supports the hypothesis, but also suggests complicated regulation.
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| Free Research Field |
応用細胞生物学
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