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2017 Fiscal Year Final Research Report

Combined cancer immunotherapy of PD-1 antibody and c-di-GMP loaded lipid nanoparticles

Research Project

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Project/Area Number 16K15102
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical pharmacy
Research InstitutionHokkaido University

Principal Investigator

NAKAMURA Takashi  北海道大学, 薬学研究院, 助教 (20604458)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywords薬物送達学 / がん免疫療法 / 脂質ナノ粒子 / アジュバント / STING / 免疫チェックポイント阻害
Outline of Final Research Achievements

The present study demonstrated that the combination therapy of programmed cell death 1 (PD-1) antibody and lipid nanoparticles (LNP) carrying cyclic di-GMP (c-di-GMP), an agonist for the stimulator of interferon genes pathway, was effective against the PD-1 therapy resistant tumor. Moreover, the dose of PD-1 antibody was reduced by combining the lipid nanoparticles. Thus, the c-di-GMP loaded LNP can be potent candidate for the combination therapy with PD-1 antibody.

Free Research Field

薬物送達学

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Published: 2019-03-29  

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