Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15117
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Hiroaki Sakurai 富山大学, 大学院医学薬学研究部(薬学), 教授 (00345571)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: がん / シグナル伝達 / 代謝 / グルコース / Nrf2

Outline of Final Research Achievements

We analyzed the effects of Bardoxolone-methyl (BAR), a small molecule activating agents of Nrf2 transcription factor, on cell migration and glucose metabolism in human breast cancer MCF-7 cells. BAR inhibited glycolysis, mitochondrial oxidative phosphorylation, and cell migration via increase in intracellular reactive oxygen species and decrease in glutathione level.

Free Research Field

分子生物学