2017 Fiscal Year Final Research Report
Development of transdermal penetration enhancer by regulating epidermal tight junction barriers
Project/Area Number |
16K15161
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
|
Research Institution | Osaka University |
Principal Investigator |
Yagi Kiyohito 大阪大学, 薬学研究科, 教授 (70166479)
|
Co-Investigator(Kenkyū-buntansha) |
渡利 彰浩 大阪大学, 薬学研究科, 講師 (80452465)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | 経皮吸収 / 表皮 / Homoharringtonine / Tight Junciton / Claudin |
Outline of Final Research Achievements |
In this study, we evaluated the transdermal absorption-promoting effect of Homoharringtonine (HHT) both in vitro and in vivo. HHT exhibited a transdermal absorption-promoting effect for macromolecules up to 10,000 Da in size, and reduced the expression of TJ components that are important for construction of the skin TJ barrier, including claudin-1, claudin-4, and occludin. Furthermore, HHT enhanced absorption of DNA/RNA heteroduplex oligonucleotide through skin. These findings indicated that HHT acts on the epidermal TJ barrier and may serve as a novel transdermal absorption-promoting agent that permits the passage of high-molecular-weight drugs such as biopharmaceuticals.
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Free Research Field |
生物薬学
|