Analysis of gene regulartory network dynamics governing tissue mechanics

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15172
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Yamaguchi University
• Principal Investigator: SEIKI Makoto 山口大学, 医学(系)研究科(研究院), 教授 (50226619)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: Hippoシグナル / KTR プローブ / YAP

Outline of Final Research Achievements

Since the transcription co-activator YAP has a unique function to promote regeneration, it is important to reveal the dynamics of Hippo signaling that govern YAP activity. In the present study, we introduced the KTR (Kinase Translocation Reporter) technology and attempted to develop the KTR probe for the Lats kinase that govern the Hippo-signaling. We generated 22 different KTR probes using the sequence of YAP which is the target of Lats kinase. We will continue to further improve the KTR probe to establish the system.

Free Research Field

発生生化学