Development of new technology to analyze cellular interaction between neuron and glial cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15240
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Keio University
• Principal Investigator: KOHYAMA JUN 慶應義塾大学, 医学部(信濃町), 准教授 (30437511)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 細胞間相互作用 / アストロサイト / 神経変性疾患

Outline of Final Research Achievements

It is becoming apparent that cellular interaction between neuronal cells and glial cells contributes to pathogenesis of neurodegenerative disease. I have developed a system to analyze the transcriptome of cocultured neurons and glial cells without mechanical isolation. Using this system, I discovered unique features in neurodegenerative patient-derived astrocytes, which lead to novel therapeutic application.

Free Research Field

神経科学