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2017 Fiscal Year Final Research Report

Regulation of innate immune responses via interaction between viral RNA sensors and the endogenous RNAs

Research Project

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Project/Area Number 16K15279
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionChiba University

Principal Investigator

Yoneyama Mitsutoshi  千葉大学, 真菌医学研究センター, 教授 (40260335)

Research Collaborator ONOMOTO Koji  
JOGI Michihiko  
SAKUMA Chiaki  
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords免疫学 / RNA
Outline of Final Research Achievements

In this study, we tried to examine whether the viral RNA sensor molecule, RIG-I-like receptor (RLR), can recognize endogenous RNA(s) and trigger anti-viral innate immune responses to regulate an unknown physiological activity. Our results demonstrate that several kinds of 5’ppp-containing endogenous RNAs, which are transcribed by RNA polymerase III, induce type I interferon-activating signal in RIG-I-dependent manner, suggesting an possible importance of interaction between viral RNA sensor molecule and self-RNA.

Free Research Field

分子生物学

URL: 

Published: 2019-03-29  

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