2017 Fiscal Year Final Research Report
Regulation of innate immune responses via interaction between viral RNA sensors and the endogenous RNAs
| Project/Area Number |
16K15279
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
ONOMOTO Koji
JOGI Michihiko
SAKUMA Chiaki
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 免疫学 / RNA |
|---|
| Outline of Final Research Achievements |
In this study, we tried to examine whether the viral RNA sensor molecule, RIG-I-like receptor (RLR), can recognize endogenous RNA(s) and trigger anti-viral innate immune responses to regulate an unknown physiological activity. Our results demonstrate that several kinds of 5’ppp-containing endogenous RNAs, which are transcribed by RNA polymerase III, induce type I interferon-activating signal in RIG-I-dependent manner, suggesting an possible importance of interaction between viral RNA sensor molecule and self-RNA.
|
| Free Research Field |
分子生物学
|
