Antigen-specific regulation of T cell response by anti-MHC antibodies

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15290
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: Hisashi Arase 大阪大学, 微生物病研究所, 教授 (10261900)
• Co-Investigator(Renkei-kenkyūsha): KISHIDA Kazuki 大阪大学, 微生物病研究所, 特任研究員 (90755662)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 免疫制御 / 抗体 / MHC

Outline of Final Research Achievements

MHC class II molecules play an important role by presenting peptides to helper T cells. We have found that antibodies against peptide/MHC class II complex are produced during immune response. In this study, we analyzed the anti-peptide/MHC class II complex antibodies. We found that anti-peptide/MHC class II complex antibodies are produced by specific peptide sequence, block T cell response and suppress autoimmune diseases. These findings suggested that anti-peptide/MHC class II complex antibodies play an important role by suppressing T cell response.

Free Research Field

免疫学