2017 Fiscal Year Final Research Report
Development of a novel tumor immunotherapy targeting CD200 receptor
| Project/Area Number |
16K15291
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
|
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 免疫監視 / 腫瘍免疫 / 免疫抑制分子 / 抗原提示細胞 / T細胞 / 抗体療法 |
|---|
| Outline of Final Research Achievements |
In this study, we examined the function of anti-CD200R mAb and its ability to enhance T-cell responses. We revealed that the injection with anti-CD200R mAb exhibited a specific depletion of CD200R+cells in mice. Furthermore, the injection with anti-CD200R mAb resulted in the enhancement of T-cell responses. On the other hand, we examined the anti-tumor effect of anti-CD200R mAb based on the specific depletion of CD200R+cells in tumor-bearing mice. We showed that the injection with anti-CD200R mAb caused the enhancement of T-cell responses and anti-tumor effect.
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| Free Research Field |
免疫学
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