Development of a At-211 imaging method with a Compton camera for targeted alpha-particle radiotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15351
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Kawachi Naoki 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員(定常) (70414521)
• Co-Investigator(Renkei-kenkyūsha): NAGAO Yuto 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 技術員 (60622545) ; YAMAGUCHI Mitsutaka 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員 (10375404) ; ISHIOKA Noriko 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員 (30354963) ; WATABE Hiroshi 国立大学法人東北大学, サイクロトロンラジオアイソトープセンター, 教授 (40280820)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: コンプトンカメラ / 標的アイソトープ治療

Outline of Final Research Achievements

Astatine-211 is a promising radionuclide for targeted radiotherapy. It is important to acquire an image of the distribution of targeted radiotherapeutic agents in a patient's body for optimization of treatment strategies. We proposed to image At-211 quantitatively with high-energy photons to overcome some problems in conventional planar gamma camera or single-photon emission computed tomography imaging. We performed an imaging experiment of a point-like At-211 source using a Compton camera, and demonstrated the capability of imaging At-211 with the high-energy photons for the first time.

Free Research Field

放射線計測