A new approach to elucidate the risk of malignant lymphoma in atomic bomb survivors

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K15358
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Nagasaki University
• Principal Investigator: IWANAGA Masako 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00372772)
• Co-Investigator(Kenkyū-buntansha): 新野 大介 長崎大学, 医歯薬学総合研究科(医学系), 客員教授 (20426563)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 悪性リンパ腫 / malignant lymphom / 原爆被ばく者 / atomic bomb survivors / 放射線被曝 / Radiation exposure / がん登録 / cancer registry

Outline of Final Research Achievements

There has been no consensus for the relationship between increased radiation exposure and the increased risk of malignant lymphoma among atomic-bomb (AB) survivors. Previous reports of AB survivors have evaluated any lymphomas only by dividing into two major groups, Hodgkin and non-Hodgkin lymphomas; therefore, information has been limited wherther there were any differences in the incidence by cell-lineage and by maturity patterns of malignant lymphoma. The present study, therefore, investigated whether there are any differences in the cell-lineage and by maturity patterns of lymphomas between general population and AB survivors based on data from the Nagasaki-prefectural cancer registry and the Nagasaki AB survivors database. As a result, we found that there was signinificant difference in the cell-linearge proportion between AB survivors and non-survivors, B-cell lymphoma was predominant for AB survivors whereas T-cell lymphoma was predominant for non-survivors.

Free Research Field

臨床疫学　がん疫学　血液内科学

Academic Significance and Societal Importance of the Research Achievements

放射線被曝と悪性リンパ腫発症との関連は、骨髄系腫瘍とは異なり一定の見解が得られていませんでした。そこで本研究は長崎県がん登録に登録されたリンパ系腫瘍を詳細に分類し一般集団と原爆被曝者集団で腫瘍のタイプごとに発症割合を比較しました。その結果、原爆被曝者ではB 細胞リンパ腫が多く、一般集団では T 細胞リンパ腫が多いという違いを認めました。違いの理由については今後の詳細な研究が必要です。