Development of neuro and cardiac toxicity models considering disposition and interactions of toxic chemicals

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15404
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Legal medicine
• Research Institution: Hiroshima University
• Principal Investigator: Ohta Shigeru 広島大学, 医歯薬保健学研究科(薬), 教授 (60160503)
• Co-Investigator(Kenkyū-buntansha): 奥田 勝博 旭川医科大学, 医学部, 助教 (00389115) ; 佐能 正剛 広島大学, 医歯薬保健学研究科(薬), 助教 (00552267) ; 古武 弥一郎 広島大学, 医歯薬保健学研究科(薬), 准教授 (20335649) ; 清水 惠子 旭川医科大学, 医学部, 教授 (90312462)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 薬毒物 / 毒性 / 代謝 / 心筋細胞 / 神経細胞 / 肝細胞 / スフェロイド

Outline of Final Research Achievements

The main causes of poisoned to death by toxic chemicals are consciousness disorder, convulsions, arrhythmia and heart failure. Therefore, it is necessary to consider toxicity mechanism in the brain and the heart. Moreover, it is also necessary to consider the contribution of the metabolites formed in the liver to toxicity. In this study, we have constructed an in vitro toxicity evaluation system that reflected the in vivo function, such as three-dimensional culture system using myocardial cells, neurons, and hepatocytes, and have studied the toxicity mechanism of toxic chemicals.

Free Research Field

毒性学