Stress causes bacterial translocation: Analysis by high sensitive measurement method

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15413
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kyushu University
• Principal Investigator: Sudo Nobuyuki 九州大学, 医学研究院, 教授 (60304812)
• Co-Investigator(Kenkyū-buntansha): 古賀 泰裕 東海大学, 医学部, 教授 (60170221) ; 吉原 一文 九州大学, 医学(系)研究科(研究院), 講師 (20444854) ; 山下 真 九州大学, 大学病院, 助教 (40770805) ; 波夛 伴和 九州大学, 大学病院, 助教 (10535983)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 腸内細菌 / ストレス / バクテリアルトランスロケーション / セロトニン / 炎症性腸疾患

Outline of Final Research Achievements

Recently, there is an increasing interest in the interaction between indigenous microbes and the host, called the inter-kingdom signaling.
In this study, we found that LED209, an inhibitor of CA-mediated IKS, ameliorated mucosal inflammation in animal models of inflammatory bowel diseases, and that biologically-active serotonin were present in the gut lumen , but some of them were inactive and glucuronide-conjugated.
These results suggest that the CA-mediated IKS might play an important role in pathophysiology of inflammatory bowel diseases. They also indicate that gut microbes are indispensable for the generation and metabolism of gut lumen serotonin.

Free Research Field

心身医学