2017 Fiscal Year Final Research Report
Investigation of the significance of MRTF-A, a co-activator of SRF, in the development of obesity that is an underlying risk factor for cardiovascular diseases
| Project/Area Number |
16K15442
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 分子心臓学 / 転写因子 / シグナル伝達 / 糖代謝 / 肥満 |
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| Outline of Final Research Achievements |
Metabolic syndrome derived from central obesity and fat accumulation underlies the development of cardiovascular disease. Detailed molecular mechanisms leading to central obesity and fat accumulation remains unresolved. Recently, our study group found that MRTF-A, Rho-dependent transcriptional coactivator of SRF, plays a significant role in the regulation of adipocyte proliferation, fat accumulation and glucose metabolism by analyzing MRTF-A knockout mice. In this study, we investigated the precise molecular mechanisms and potential clinical relevance of MRTF-A in adipocyte differentiation and fat accumulation that lead to the development of metabolic syndrome and obesity
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| Free Research Field |
循環器内科学
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