The investigation and analysis for developing next-generation functional foods against lifestyle-related diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15487
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: Iwabu Miki 東京大学, 医学部附属病院, 特任准教授 (70392529)
• Co-Investigator(Renkei-kenkyūsha): IWABU Masato 東京大学, 医学部附属病院, 特任准教授 (30557236) ; YAMAUCHI Toshimasa 東京大学, 医学部附属病院, 准教授 (40372370) ; KADOWAKI Takashi 東京大学, 医学部附属病院, 教授 (30185889)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 糖尿病 / 食品 / 農林水産物 / 生体機能利用

Outline of Final Research Achievements

The aim of this research was to generate scientific evidence for vegetables, fruits and their processed products that may serve as a basis for developing next-generation functional foods directed toward promoting adiponectin/AdipoR action, thereby establishing novel preventive measures against lifestyle-related diseases. In this research, vegetable ingredients/functional substances with lifestyle-related disease-counteractive properties were identified in experiments using cultured cells. Again, all identified vegetable ingredients/functional substances were examined for their glucose-lowering properties in animal models of lifestyle-related diseases (in preparation). Furthermore, these vegetable ingredients/functional substances were examined for their acute and chronic toxicity profile to explore their potential for product development.

Free Research Field

生化学・分子生物学・糖尿病学・代謝学・病態栄養学