2017 Fiscal Year Final Research Report
Clonal evolution of tumor-infiltrating cells in T-cell lymphomas
| Project/Area Number |
16K15497
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | T細胞リンパ腫 / TET2 |
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| Outline of Final Research Achievements |
We previously identified that multistep acquisition of mutations are the important mechanisms for T-cell lymphomas. Mutations in TET2 gene, encoding an epigenetic modifier are the key for evolution of premalignant cells. The RHOA mutations are the driver for development of T-lineage tumor cells from premalignant cells. In this study, we established a mouse model showing that the tumors are supported by tumor-infiltrating cells evolved from premalignant cells.
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| Free Research Field |
血液腫瘍学
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