Analysis of signal transduction mechanisms by chitin through Chitinase-like proteins.

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15515
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: Saito Hirohisa 国立研究開発法人国立成育医療研究センター, 研究所, 副所長 (40130166)
• Co-Investigator(Renkei-kenkyūsha): NAKAE SUSUMU 東京大学, 医科学研究所, 准教授 (60450409) ; MATSUMOTO KENJI 国立研究開発法人国立成育医療研究センター研究所, 免疫アレルギー感染研究部, 部長 (60181765) ; SUDO KATSUKO 東京医科大学, 医学部, 講師 (50126091)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: キチン / Ｔｈ２ / アレルギー

Outline of Final Research Achievements

Although it is considered that chitin (a major component of the outer shell of house dust mite) can contribute to the induction of allergic responses, it still remains unclear the mechanism of cellular signal transduction by stimulation of chitin. Previously, we identified a Chitinase-like protein as a signal transducer molecule of chitin. In this study therefore, we attempted to identify membrane receptors for the complex of chitin/Chitinase-like protein, but could not clarify the molecule. In the future, we should change the method of screening for identification of the receptors for chitin and Chitinase-like protein complex.

Free Research Field

免疫学、アレルギー学