Analysis of mesolimbic dopaminergic neuron (A10) induced from patients of mental disorders

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15561
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kobe University
• Principal Investigator: Sora Ichiro 神戸大学, 医学研究科, 教授 (40322713)
• Co-Investigator(Kenkyū-buntansha): 毛利 健太朗 神戸大学, 保健管理センター, 助教 (00642125) ; 菱本 明豊 神戸大学, 医学研究科, 准教授 (50529526) ; 朴 秀賢 神戸大学, 医学研究科, 講師 (60455665)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: Otx2 / Sox6

Outline of Final Research Achievements

Factors related to the differentiation and induction of the nigrostriatal dopamine neuron (A9) and the mesolimbic dopamine neuron (A10) were analized with SDIA（Stromal cell Derived Inducing Activity）method. As a result of examining differentiation and induction to dopaminergic neurons with SDIA method in various periods, it was found that Otx 2 and Sox 6 are expressed in about 3 weeks. Cells in which Otx 2 and Sox 6 are overlappingly expressed were not observed. Culture with dopamine neurons by SDIA method was thought to differentiate into and induce the nigrostriatal dopamine neuron (A9) and the mesolimbic dopamine neuron (A10) in about 3 weeks.

Free Research Field

精神医学