2018 Fiscal Year Final Research Report

Is it necessary to prepare a dose-response curve for dose evaluation applied to metabolic syndrome?

Research Project

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Project/Area Number	16K15569
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Hirosaki University
Principal Investigator	Miura Tomisato 弘前大学, 保健学研究科, 准教授 (20261456)
Co-Investigator(Kenkyū-buntansha)	阿部悠福島県立医科大学, 医学部, 助教 (00722472) 葛西宏介弘前大学, 保健学研究科, 講師 (50400148) 有吉健太郎弘前大学, 被ばく医療総合研究所, 助教 (50462750) 吉田光明弘前大学, 被ばく医療総合研究所, 教授 (60182789) 中田章史北海道科学大学, 薬学部, 准教授 (70415420)
Project Period (FY)	2016-04-01 – 2019-03-31
Keywords	バイオドシメトリー / 慢性炎症 / 糖尿病 / 放射線生物影響
Outline of Final Research Achievements	Inflammation contributes to increased risk of radiation damage. However, its reliability may be affected by the presence of chronic inflammation. As chronic inflammation-related diseases such as obesity and type 2 diabetes mellitus (T2DM) become more prevalent, it becomes an important point of consideration for dose estimation as many of the dose calibration curves are generated using ex vivo irradiated healthy human blood. The presence of chronic inflammation seemed to play a role in increasing the amount of chromosomal aberrations and DNA damage after radiation, which can affect dose estimation. Dic was the most radiation-specific biomarker, but it was also significa1ntly increased in the presence of chronic inflammation after irradiation. Despite an increase in DNA damage markers, histological analysis in the small intestine and spleen did not reveal clear differences between ob/ob and B6J mice.
Free Research Field	生物学的線量評価
Academic Significance and Societal Importance of the Research Achievements	同線量の被ばく線量にもかかわらず、2型糖尿病マウスでは野生型マウスに比べ染色体異常頻度やDNA損傷レベルが増加したことは、被ばく患者の生物学的線量評価において患者の生活習慣病等の健康状態を考慮した線量評価が必要となることを示唆している。さらに、糖尿病などの慢性炎症を有する患者では、DNA損傷レベルが増加する可能性があり、被ばく後の晩発影響の増悪化が危惧される。本研究は被ばく医療における線量評価や健康リスクの解明において、個人の健康状態の把握が必要となることを示唆しており、今後の緊急被ばく医療における課題を提示した。