Development of nanoparticles which can detect and treat cancer simultaneously

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15572
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Gonda Kohsuke 東北大学, 医学系研究科, 教授 (80375435)
• Co-Investigator(Kenkyū-buntansha): 大内 憲明 東北大学, 医学系研究科, 客員教授 (90203710) ; 亀井 尚 東北大学, 医学系研究科, 教授 (10436115)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: がん / 温熱療法 / リンパ節 / 転移 / ナノ粒子 / イメージング / X線 / 光

Outline of Final Research Achievements

Hyperthermia has been studied for a long time for treating tumors. Recently, an application of gold (Au) nanorods (AuNRs), possessing high photothermal capability, in hyperthermia has attracted attention. To apply AuNRs in photothermal therapy of metastatic lymph nodes in mice, we produced AuNRs coated with silica (AuNR/SiO2). AuNR/SiO2 did not have cytotoxicity. When the AuNR/SiO2 nanoparticles were injected into the tumor of the model mouse with lymphatic metastasis, X-ray computed tomography showed that the nanoparticles were delivered to the metastatic lymph nodes and afferent lymphatic vessels. Then irradiation of the metastatic lymph nodes with a 700-nm laser was conducted. We successfully completed photothermal therapy of the metastatic lymph nodes.

Free Research Field

医工学