Postanesthetic effect depending on sex and development

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15678
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Yokohama City University
• Principal Investigator: GOTO Takahisa 横浜市立大学, 医学研究科, 教授 (00256075)
• Co-Investigator(Kenkyū-buntansha): 宮崎 智之 横浜市立大学, 医学部, 准教授 (30580724) ; 高瀬 堅吉 自治医科大学, 医学部, 教授 (80381474)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 吸入麻酔薬 / アルツハイマー病

Outline of Final Research Achievements

Previously we have examined post-anesthetic effect on higher brain function with comprehensive behavioral test battery. In this study we focused on the difference among development about these effects. Studying aged and AD model mice, AD mice exhibited increased locomoter activity and decreased depression. Exposure AD mice to desflurane reduced increased locomoter activity to some extent. However, overall we didn't find any significant effect of desflurane on APP-KI.

Free Research Field

麻酔科学