2017 Fiscal Year Final Research Report
Analysis of the effect on fetus, by single and continuous administration of oxytocin to pregnant mother prairie vole.
| Project/Area Number |
16K15698
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹田 省 順天堂大学, 医学部, 特任教授 (20143456)
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| Research Collaborator |
HIDEMA Shizu
YADA Saori
HIRAYAMA Takashi
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 誘発分娩 / 自閉症スペクトラム障害 / 平原ハタネズミ / CRISPR/Cas9 / 浸透圧ポンプ / ペア形成行動 |
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| Outline of Final Research Achievements |
Oxytocin (OXT) is neuromodulator controlling social and prosocial behaviors in animals, and expected as a new drug curing patients of Autistic Spectrum Disorders (ASD). Impaired social behaviors are also known as a core symptom of ASD patients. On the other hand, OXT has been widely used as labor-inducing drug in the area of gynecology. However, recent epidemiological studies reported that exposure of fetus to exogenously administrated OXT might be a risk factor to induce ASD. We studied the effect of exogenously administrated OXT on fetus, and it might induce brain ischemia during induced labor led to cell death in several nuclei, which were implicated as impaired nuclei in mental disorders, however we haven’t found any abnormal social behavior with pups after birth. We continuously need to assess the safety of administrated OXT on pups until their adulthood.
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| Free Research Field |
行動神経内分泌学、分子神経生理学、分子生物学
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