Acquired tolerance during pregnency, a challenge towards the application to oncology/transplantation

2017 Fiscal Year Annual Research Report

• Project/Area Number: 16K15699
• Research Institution: Akita University
• Principal Investigator: 寺田 幸弘 秋田大学, 医学(系)研究科(研究院), 教授 (10260431)
• Co-Investigator(Kenkyū-buntansha): 佐藤 直樹 秋田大学, 医学(系)研究科(研究院), 准教授 (40447199) ; 清水 大 秋田大学, 医学部, 講師 (60400503) ; 佐藤 敏治 秋田大学, 医学(系)研究科(研究院), 助教 (70636183)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: マイクロキメリズム / 免疫寛容機構 / キメラ

Outline of Annual Research Achievements

本研究は母体-胎児間での細胞の相互交換現象であるマイクロキメリズムの成立機序の解明とその免疫寛容機構の移植医療及びがん治療への応用を目的としていた。
本研究の鍵となるモデル動物作製については２年間関連する腫瘍関連、生殖工学関連の学会等で情報を収集し試みたが安定した作成系を得るにはいたらなかった。　しかしながらそれに派生したいくつかの婦人科腫瘍に関する知見を得た。　卵巣成熟嚢胞性奇形種は卵子の単為発生をその起源とし、臨床的にもきわめて発生頻度の高い卵巣腫瘍である。　若年者で再発を繰り返した同疾患の組織についてマイクロアレイ解析を行い、正常群との比較が進んでいる。　卵子活性化に関連する遺伝子において正常群との差異がみとめられている。　また、それらの組織中のマイクロキメラの発現程度についても解析をすすめてゆく予定である。

Research Products

• [Journal Article] Leaflets and continual educational offerings led to increased coverage rate of newborn hearing screening in Akita. (2018)
  • Author(s): Sato T,Nakazawa M,Takahashi S,Mizuno T,Sato A,Noguchi A,Sato M,Katagiri S,Yamada T
  • Journal Title: Auris Nasus Larynx Volume: 44 Pages: 673～679
  • DOI: 10.1016/j.anl.2017.11.014.
  • Peer Reviewed / Open Access
• [Journal Article] The location of “8”-shaped hatching influences inner cell mass formation in mouse blastocysts (2017)
  • Author(s): Onodera Y,Takahashi K ,Goto M,Anzai M,Ono N,Shirasawa H,Sato W,Miura H,Sato N ,Sato A,Kumazawa Y,Terada Y
  • Journal Title: PLOS ONE Volume: 12 Pages: e0175150
  • DOI: 10.1371/journal.pone.0175150
  • Peer Reviewed / Open Access
• [Journal Article] Food Intake Affects Sperm-Egg Fusion Through the GIP/PSG17 Axis in Mice (2017)
  • Author(s): Shimizu T,Sato T,Tsukiyama K,Fujita H,Kato S,Hoizumi M,Shirasawa H,Narita T,Terada Y,Seino Y,Yamada Y
  • Journal Title: Endocrinology Volume: 158 Pages: 2134～2144
  • DOI: 10.1210/en.2016-1861
  • Peer Reviewed / Open Access
• [Journal Article] Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women. (2017)
  • Author(s): Tanaka H,Shirasawa H,Shimizu D,Sato N,Ooyama N,Takahashi O,Terada Y
  • Journal Title: J Obstet Gynaecol Res Volume: 43 Pages: 1597～1601
  • DOI: 10.111/jog.13419
  • Peer Reviewed / Open Access
• [Journal Article] In vitro maturation of human immature oocytes for fertility preservation and research material (2017)
  • Author(s): Shirasawa H,Terada Y
  • Journal Title: Reproductive Medicine and Biology Volume: 16 Pages: 258～267
  • DOI: 10.1002/rmb2.12042
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of Lynch-like cases collaterally classified by Lynch syndrome identification strategy using universal screening in endometrial cancer (2017)
  • Author(s): Takahashi K,Sato N,Sugawara T,Kato A,Sato T,Shimizu D,Tamura D,Kito M,Makino K,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Terada Y
  • Journal Title: Gynecologic Oncology Volume: 147 Pages: 388～395
  • DOI: 10.1016/j.ygyno.2017.08.016
  • Peer Reviewed / Open Access
• [Journal Article] A case of placental site trophoblastic tumor complicated nephrotic syndrome in which hysteroscopic biopsy did not yield a definitive diagnosis. (2017)
  • Author(s): Sato W,Miura Y,Shirasawa H,Kumazawa Y,Kumagai J,Terada Y
  • Journal Title: Gynecology and Minimally Invasive Therapy Volume: 6 Pages: 69～72
  • Peer Reviewed
• [Journal Article] A nationwide ecological study using the national database of health insurance claims. (2017)
  • Author(s): Maeda E,Ishihara O,Tomio J,Sato A,Terada Y,Kobayashi Y,Murata K
  • Journal Title: Obstetrics and Gynecology Research Volume: 44 Pages: 208～216
  • DOI: 10.1111/jog.13518.
  • Peer Reviewed / Open Access
• [Journal Article] 子宮体癌におけるリンチ症候群のスクリーニング戦略. (2017)
  • Author(s): 菅原多恵，佐藤直樹，加藤彩，髙橋和江，清水大，佐藤敏治，牧野健一，木藤正彦，田村大輔，寺田幸弘
  • Journal Title: 日本家族性腫瘍学会誌 Volume: 16 Pages: 44～49
  • Peer Reviewed
• [Presentation] MED12 Mutationin UterineAdenomyoma. (2017)
  • Author(s): Kito,M.,Maeda,D.,Terada,Y.,Goto,A
  • Organizer: The United States & Canadian Academy of Pathology’s 106th Annual Meeting
  • Int'l Joint Research
• [Presentation] Uterine Adenomatoid Tumor: A Neoplasm Having Frequent Association With Immunosuppressive Therapy. (2017)
  • Author(s): Tamura,D
  • Organizer: The 5th Biennial Meeting of Asian Society of Gynecologic Oncology（ASGO2017）
  • Int'l Joint Research