Development of a monitoring system to estimate in vivo tissue injury using chemometric analysis of near infrared spectra

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15760
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kyoto University
• Principal Investigator: Koike Kaoru 京都大学, 医学研究科, 教授 (10267164)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: 近赤外スペクトル / 臓器障害 / リアルタイム / モニタリング / 小腸 / 虚血 / 再灌流

Outline of Final Research Achievements

Near infrared (NIR) spectroscopy is a noninvasive, contactless and real-time analytical technology that may yield a variety of promising bedside monitoring systems in the field of emergency and critical care medicine. After intestinal ischemia (3h) or intestinal ischemia/reperfusion (3h/1h) was conducted in rats by superior mesenteric artery occlusion, NIR spectra of the intestine were obtained in vivo using ultra-compact NIR spectrometer. When the full range of NIR spectra observed were analyzed by chemometric technique, the temporal change of intestinal tissue injury was clearly estimated.

Free Research Field

救急医学