Development of novel diagnostic technology for marfan syndrome using periodontal tissue

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15844
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Periodontology
• Research Institution: Tohoku University
• Principal Investigator: Saito Masahiro 東北大学, 歯学研究科, 教授 (40215562)
• Co-Investigator(Kenkyū-buntansha): 吉田 恭子 (今中恭子) 三重大学, 医学系研究科, 准教授 (00242967) ; 石河 真幸 東北大学, 大学病院, 助教 (60432936)
• Co-Investigator(Renkei-kenkyūsha): 石河 真幸 東北大学, 歯学研究科, 助教 (60432936)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 結合組織疾患

Outline of Final Research Achievements

Marfan syndrome is a genetic connective tissue disease that caused by mutation of fibrillin-1 that is a major component of microfibril. Main cause of death of marfan syndrome is aortic aneurysm and dissection, however no reliable diagnostic method is available at present. In this project, we tried to develop a novel diagnostic technology of aortic aneurysm and dissection that investigating microfibril structure using anti-fibrillin-1 antibody. We generated immunostaining technology that is able to stain microfibril in the human aorta using anti-fibrillin-1 antibody. The diagnostic technology that suspect aortic aneurysm and dissection is going to develop by using gigival tissue obtained from marfan syndrome patient.

Free Research Field

歯科保存学