Proposal of novel etiology of periodontal infection: Intratissue infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15853
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Osaka University
• Principal Investigator: Amano Atsuo 大阪大学, 歯学研究科, 教授 (50193024)
• Co-Investigator(Kenkyū-buntansha): 竹内 洋輝 大阪大学, 歯学研究科(研究院), 助教 (40572186)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: Porphyromonas gingivalis / 歯周病 / 細胞内寄生 / Rab14 / RalA / VAMP2

Outline of Final Research Achievements

Porphyromonas gingival, a periodontal pathogen, is well known to invade host cells such as gingival epithelial cells. However, its intercellular dynamics is unknown. The present study indicated its intracellular trafficking. P. gingivalis was first internalized with early endosomes positive for Rab14 and RalA which are members of low molecular weitht GTP-binding proteins. Then, the intercellular pathogen was suggested to exploit these effector molecules for its intracellular inhabiting and exit from infected cells.

Free Research Field

予防歯科学