Improvement and evaluation of blood oxygenation measurement system based on photoacoustic technique

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K16413
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: National Defense Medical College
• Principal Investigator: Takeshi Hirasawa 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 医用工学, 助教 (60583086)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 光音響イメージング / 血液酸素飽和度計測 / 分光イメージング / 非侵襲計測

Outline of Final Research Achievements

Purpose of this study is to develop a non-invasive blood oxygen saturation measurement method based on photo acoustic imaging technique. In photoacoustic imaging, pulsed light was irradiated to a biological tissue, and then ultrasound that was produced from blood inside biological tissue that absorbed pulsed light was measured. In this research, we developed both devise and algorithm for blood oxygen measurement, established animal model, and performed animal experiment to evaluate the accuracy. In addition, we discussed a new blood oxygen measurement technique that is not suffered from attenuation of light and ultrasound inside biological tissue, those were main cause of measurement error in existing photoacoustic technique.

Free Research Field

医用工学

Academic Significance and Societal Importance of the Research Achievements

血液酸素飽和度は，生体内におけるエネルギー産生に必要な酸素の供給状態を把握するうえで，重要な指標の一つです。採血した血液を分析する手法が標準的な計測法ですが，患者に対する負担が大きい問題があります。全身的な酸素供給状態を把握する目的では，採血を伴わないパルスオキシメータを使用可能ですが，局所的な酸素供給状態の把握する目的では依然として患者への負担を伴う手法がとられています。そこで本研究では，生体局所の血管内の血液酸素飽和度を体表から繰返し計測可能な技術を開発するための技術を開発し，評価しました。