2018 Fiscal Year Final Research Report
Research of hexanal induced signaling mechanism in B16 melanoma cells
| Project/Area Number |
16K16598
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
Yuki Ishikawa 東京海洋大学, 学術研究院, 博士研究員 (50638004)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | ヘキサナール / メラノーマ / Ｂ16細胞 / カルシウム応答 / ｎ-６系脂質 |
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| Outline of Final Research Achievements |
In this research, we investigated that mechanism of hexanal-induced calcium response in B16 melanoma cells. TRPA1 channel and olfactory receptors that of reported hexanal reception molecules were not involved in calcium response of B16 melanoma cells. On the trials of tumor model mouse experiment using B16 cells administration to tail vein, tumor weight was gained by hexanal exposure. The results suggest that some kind of cancer cells has a signaling pathway via unknown molecule that activated by hexanal.
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| Free Research Field |
生化学 食品化学 水産化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究より，ある種のガン細胞では，生体内で生じるヘキサナールを特異的に認識する，これまでに報告のない分子機構を有し，それがガンの成長・促進に関与しうる可能性が示唆された．今後ガンの制御に関わる因子の一つとして，ヘキサナールを介した情報伝達経路という，これまでほとんど着目されてこなかったターゲットの存在が明らかとなった．
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