Encoding of episodic memory triggers rapid synaptic plasticity in the hippocampal CA1

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K17362
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental psychology
• Research Institution: Yamaguchi University
• Principal Investigator: SAKIMOTO Yuya 山口大学, 大学院医学系研究科, 助教 (40634390)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 海馬CA1 / エピソード記憶 / patch clamp

Outline of Final Research Achievements

In this project, we focused on rats' hippocampal synaptic plasticity within 1 hour time period after a presentation of episodic events in inhibitory avoidance task. In the slice patch clamp methods, mEPSC and mIPSC amplitude increased at the 5 min after learning. Also, the results of paired pulse ratio showed an increase of probability of glutamate release. In addition, in westernblotting methods,　it increased the number of GABAA receptors on the hippocampal synapses. Thus, we suggest that it plays critical role for formation of episodic memory in the balance of excitatory and inhibitory input from synapses.

Free Research Field

神経生理学