2017 Fiscal Year Final Research Report
Development of a novel method to generate nitrogen-centered radical species and its application to amination reactions
| Project/Area Number |
16K17868
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 超原子価ヨウ素 / ヨウ素 / アミノ化 / ラジカル |
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| Outline of Final Research Achievements |
In the presence of a metal catalyst, the amination of a C－H bond of aromatic compounds by a nitrogen-centered radical species generated from a hypervalent iodine reagent containing a phthalimidate proceeded to afford aniline derivatives albeit in low yield. In addition, an amination of enol silyl ether derived from various ketones proceeded effectively to provide α-aminated ketones in good yields. These results demonstrate a novel reactivity of hypervalent iodine reagents containing a phthalimidate.
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| Free Research Field |
有機合成化学
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