2017 Fiscal Year Final Research Report
Importance of histamine metabolizing enzyme in the brain
| Project/Area Number |
16K18389
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ヒスタミン |
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| Outline of Final Research Achievements |
HIstamine acts as a neurotransmitter in the central nervous system. In this study,I examined the importance of a histamine metabolizing enzyme for brain functions. I revealed the essential role of this enzyme in the regulation of brain histamine and the contribution to brain functions such as sleep-wake cycle and aggression. Previous reports showed that brain histamine concentration was decreased in various brain diseases. Thus, I tried to develop new inhibitors against the histamine metabolizing enzyme to increase brain histamine concentration. I have confirmed that several compounds have sufficient inhibitory effects on the histamine metabolizing enzyme.
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| Free Research Field |
神経薬理学
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