2017 Fiscal Year Final Research Report
Elucidation of the role of glutamine as a metabolic signaling molecule in cancer stem cells.
| Project/Area Number |
16K18410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | がん幹細胞 / グルタミン代謝 |
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| Outline of Final Research Achievements |
Cancer stem cells, which possess both self-renewal capacity and tumor initiation capacity, are thought to be involved in secondary tumor development and cancer recurrence. The roles of glutamine and its metabolites in the stemness of cancer stem cells are poorly understood. In this study, I demonstrate that glutamine depletion leads to a decrease in both expression levels of cancer stem cell markers and sphere forming capacity in pancreatic cancer stem cells. These results indicate that glutamine metabolism in cancer stem cells could be a target for cancer stem cells therapy.
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| Free Research Field |
分子腫瘍学
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