The mechanism of action of a novel small molecule that represses the Warburg effect

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K18432
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kobayashi Hiroki 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 協力研究員 (30528683)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ワールブルグ効果 / 代謝 / ケミカルバイオロジー

Outline of Final Research Achievements

The Warburg effect, a metabolic derangement in cancer cells resulting in increased glucose uptake and glycolysis, is considered as a malignant phenotype. However, the mechanism regulating the Warburg effect has remained elusive. We had identified a novel compound that inhibits the Warburg effect by phenotypic screening. In this study, we elucidated the mode of action of the compound by using metabolomic, biochemical and genetic approach. As a result, we identified the target molecule of the compound, and uncovered the mechanism regulating the balance between glycolysis and oxidative phosphorylation.

Free Research Field

ケミカルバイオロジー