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2017 Fiscal Year Final Research Report

Identification of immunosuppressive factor in tumor microenvironment in patient with lung cancer

Research Project

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Project/Area Number 16K18463
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor therapeutics
Research InstitutionKawasaki Medical School

Principal Investigator

Ohue Yoshihiro  川崎医科大学, 医学部, 講師 (70435014)

Research Collaborator Oka MIKIO  川崎医科大学, 医学部・呼吸器内科学, 教授 (40223995)
Kurose KOJI  川崎医科大学, 医学部・呼吸器内科学, 臨床助教 (30551139)
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords肺がん / がん抗原 / 免疫療法 / 免疫チェックポイント分子
Outline of Final Research Achievements

The effect of immunotherapy in lung cancer is still insufficient, and elucidation of new immunosuppressive mechanism is important. In this study, expression of PD-1 and TIM-3 on tumor-infiltrating T cells and expression of their ligands on tumor cells were examined and analyzed for correlation with survival. Expression of PD-L1 and galectin-9 and XAGE 1 antigens on tumor cells were independent prognostic factors of TNM classification (HR: 0.40, p = 0.01).
Based on the above results, the survival of patients with lung adenocarcinoma can be predicted by investigating the tumor microenvironment in detail. Furthermore, in addition to the PD-1 / PD-L1 pathway, the TIM-3 / galectin-9 pathway is also important in the tumor microenvironment and development of cancer immunotherapy that inhibits them is very important.

Free Research Field

腫瘍免疫学

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Published: 2019-03-29  

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