2017 Fiscal Year Final Research Report
Analysis of biological functions of novel histone variants
| Project/Area Number |
16K18479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ヒストンバリアント / エピゲノム制御 / ヒストンコード / クロマチン |
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| Outline of Final Research Achievements |
This project aimed to recognize the function of the novel histone variants in cell differentiation. In the mouse genome, we previously identified fourteen hitherto unknown H3 genes of which thirteen are analogous to H3.3, and reported that some of these genes were expressed in skeletal muscle. We demonstrated that one such histone H3 variant H3mm7 is preferentially expressed in quiescent satellite cells and that it is essential for myogenesis. Further chromatin analysis unveiled that H3mm7 was incorporated into the promoter regions of active gene loci including myogenic genes and that it was required for open chromatin structure to facilitate transcription. These results were published as well as three reports on human histone variants in our joint research projects.
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| Free Research Field |
エピジェネティクス
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