2017 Fiscal Year Final Research Report
Pharmacokinetics of new antiepileptic drugs and individualized therapy in pregnant women
| Project/Area Number |
16K18931
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University (2017)
Chiba University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 個別適正化 / 薬物動態 / てんかん |
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| Outline of Final Research Achievements |
Lamotrigine (LTG) is widely used among newer antiepileptic drugs in pregnant women with epilepsy. LTG is metabolized via glucuronidation by UGT1A4, and the main metabolite, LTG-2N-glucuronide is excreted in urine. The present study demonstrated that LTG clearance was well correlated with plasma LTG-2N-glucuronide/LTG ratio. Since UGT1A4 expression was induced during pregnancy, plasma LTG-2N-glucuronide/LTG ratio might be useful in individualized therapy with LTG in pregnant women.
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| Free Research Field |
医療薬学
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