2017 Fiscal Year Final Research Report
Functional analysis of FcRL molecule based on molecular recognition mechanism
| Project/Area Number |
16K18973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Kiyoshi Masato 国立医薬品食品衛生研究所, 生物薬品部, 研究員 (60754314)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | FcRL / IgG / リガンド / 安定性 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the relationship between the biological response mediated by Fc receptor-like protein (FcRL) and the efficacy / safety of antibody drugs, and to utilize it for molecular design and quality evaluation and management of antibody drugs. Moreover, this study focuses on the molecular recognition mechanism of FcRL to its ligands and perform functional analysis. We analyzed the binding properties of antibody subtype to five subtypes FcRL1, FcRL2, FcRL3, FcRL5 and FcRLB using Surface Plasmon Resonance (SPR) method.
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| Free Research Field |
蛋白質科学
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